Can Vitamin B12 Cause Acne? What the Research Says
Vitamin B12 is essential for energy production, brain function, and red blood cell formation—but could too much of it actually trigger acne?
The short answer: Yes, it can.
The Link Between B12 and Acne
Multiple studies, including this one, have explored the connection between B12 supplementation and acne breakouts. The evidence suggests that high levels of B12—particularly from supplements and injections—can contribute to an increase in Cutibacterium acnes (formerly Propionibacterium acnes), the bacteria associated with acne development.
What’s interesting is that this acne flare-up isn’t just limited to individuals already prone to breakouts. The research shows that even people with healthy skin can develop acne after B12 injections, making the connection all the more compelling.
Why Does This Happen?
The exact mechanism isn’t fully understood, but one theory is that excess B12 changes the metabolic activity of skin bacteria. When exposed to these high vitamin levels, the bacteria begin to produce inflammatory compounds that contribute to breakouts. It has also been suggested that the bacteria may use B12 to fuel their growth, although this remains speculative.
How Much is Too Much?
Most over-the-counter B12 supplements contain far more than the recommended daily amount—sometimes thousands of percent over the RDA. Since B12 is water-soluble, any excess is usually excreted in urine. However, that doesn’t necessarily make it harmless in large doses, particularly when it comes to skin health.
Injections, which deliver the vitamin directly into the bloodstream, seem to pose a higher risk for B12-induced breakouts. The takeaway here is not that you should avoid B12 altogether, but that more isn’t always better.
Final Thoughts
If you’re noticing new breakouts after starting a B12 supplement or receiving injections, it might be worth talking to your healthcare provider. While B12 is vital for overall health, moderation matters. Aim to meet your needs without going overboard—especially if you’re acne-prone or sensitive to changes in your skin microbiome.
